The American Red Cross is a participant in the FDA, NHLBI and HHS-OASH funded Transfusion-Transmissible Infections Monitoring System (TTIMS) project. TTIMS consists of two coordinating centers: The Donation Database Coordinating Center (DDCC) and the Laboratory and Risk Factor Database Coordinating Center (LRCC). The American Red Cross acts as the DDCC and Vitalant Research Institute acts as the LRCC for the study. TTIMS brings together donation and test data acquired during routine blood donation collections at four major US blood systems (American Red Cross, New York Blood Center, OneBlood and Vitalant) with data collected from specialty research studies. Together this data provides critical blood safety and monitoring information on more than 50% of the US blood supply.
The DDCC is responsible for acquiring and validating donor demographic data from the four participating blood systems plus testing results from Creative Testing Solutions, ensuring that the data available from each system are harmonized, and that appropriate consensus positive definitions are consistently applied across sites. The DDCC then analyzes and reports on the prevalence and incidence of HIV, HBV and HCV in US blood donors and donations, with special attention paid to temporal and demographic changes and trends. The DDCC also reports positive and false positive donors to the LRCC. The LRCC coordinates the Risk Factor Questionnaire study. The LRCC provides each blood center lists from which donors are interviewed by each center’s donor counselors. LRCC compiles and analyses this data. The LRCC also acts as the repository for positive samples and conducts follow-up molecular sequencing, recency and other testing of interest. The American Red Cross participates in both the DDCC and the LRCC activities.
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