The American Red Cross is a participant in the FDA, NHLBI and HHS-OASH funded Transfusion-Transmissible Infections Monitoring System (TTIMS) project. TTIMS consists of two coordinating centers: The Donation Database Coordinating Center (DDCC) and the Laboratory and Risk Factor Database Coordinating Center (LRCC). The American Red Cross acts as the DDCC and Vitalant Research Institute acts as the LRCC for the study. TTIMS brings together donation and test data acquired during routine blood donation collections at four major US blood systems (American Red Cross, New York Blood Center, OneBlood and Vitalant) with data collected from specialty research studies. Together this data provides critical blood safety and monitoring information on more than 50% of the US blood supply.
The DDCC is responsible for acquiring and validating donor demographic data from the four participating blood systems plus testing results from Creative Testing Solutions, ensuring that the data available from each system are harmonized, and that appropriate consensus positive definitions are consistently applied across sites. The DDCC then analyzes and reports on the prevalence and incidence of HIV, HBV and HCV in US blood donors and donations, with special attention paid to temporal and demographic changes and trends. The DDCC also reports positive and false positive donors to the LRCC. The LRCC coordinates the Risk Factor Questionnaire study. The LRCC provides each blood center lists from which donors are interviewed by each center’s donor counselors. LRCC compiles and analyses this data. The LRCC also acts as the repository for positive samples and conducts follow-up molecular sequencing, recency and other testing of interest. The American Red Cross participates in both the DDCC and the LRCC activities.
Steele WR, Dodd RY, Notari EP, et al. Prevalence of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in United States blood donations, 2015 to 2019: The Transfusion-Transmissible Infections Monitoring System (TTIMS) [published online ahead of print, 2020 Aug 31]. Transfusion. 2020;10.1111/trf.16005. doi:10.1111/trf.16005
Custer B, Stramer SL, Glynn S, Williams AE, Anderson SA. Transfusion-transmissible infection monitoring system: a tool to monitor changes in blood safety. Transfusion 2016;56: 1499-502.
Dodd RY, Notari EP, Nelson D, Foster GA, Krysztof DE, Kaidarova Z, Milan-Benson L, Kessler DA, Shaz BH, Vahidnia F, Custer B, Stramer SL, NHLBI REDSI. Development of a multisystem surveillance database for transfusion-transmitted infections among blood donors in the United States. Transfusion 2016;56: 2781-9.
Vahidnia F, Stramer SL, Kessler D, Shaz B, Leparc G, Krysztof DE, Glynn SA, Custer B. Recent viral infection in US blood donors and health-related quality of life (HRQOL). Qual Life Res 2017;26: 349-57.
Vahidnia F, Stramer SL, Kessler D, Goncalez TT, Shaz BH, Leparc G, Krysztof DE, Dodd RY, Glynn SA, Custer B, Nhlbi Retrovirus Epidemiology Donor Study I. Motivations for donating and attitudes toward screening policies in US blood donors with viral infection. Transfusion 2016.
Custer B, Kessler D, Vahidnia F, Leparc G, Krysztof DE, Shaz B, Kamel H, Glynn S, Dodd RY, Stramer SL, Nhlbi Retrovirus Epidemiology Donor Study I. Risk factors for retrovirus and hepatitis virus infections in accepted blood donors. Transfusion 2015;55: 1098-107.