Thank you for donating blood through the American Red Cross during this unprecedented and uncertain time. During the blood donation process, samples are collected and sent to a laboratory where they undergo routine screening and infectious disease testing. Recently, the Red Cross began screening donations for antibodies to the SARS coronavirus-2 (SARS-CoV-2), the virus that causes COVID-19.This COVID-19 antibody test is authorized by the U.S. Food and Drug Administration and may indicate if your immune system has produced antibodies to the coronavirus, regardless of whether you developed symptoms. It is unknown if the antibodies that result from a COVID-19 infection will provide someone with immunity from a future coronavirus infection.
Positive test result: Indicates potential previous exposure to the virus that causes COVID-19 resulting in the development of specific antibodies to the virus, regardless of whether you experienced COVID-19 symptoms. It does not confirm infection or immunity. It is currently unknown whether the presence of COVID-19 antibodies will provide immunity to future infection and individuals should continue to follow all COVID-19 safety guidelines provided by the CDC. As with all tests, false positives, or a test result that incorrectly states the presence of antibodies, can occur. If your test result is positive, the Red Cross may contact you to request additional information and conduct further testing as part of a research study.
Effective September 21, the Red Cross began secondary testing on donations to confirm COVID-19 antibody test results. Through this effort, plasma from standard blood donations that test positive for COVID-19 antibodies may be processed into a convalescent plasma product to help patients battling the virus.
Negative test result: Indicates that you probably have not been exposed to COVID-19 and therefore have not developed antibodies to the virus. It also could indicate that antibodies are present but at levels below the test’s threshold for detection, or that the test did not recognize those antibodies. It is possible that you can still contract the virus, if exposed. It takes one to three weeks after an infection for antibodies to be present.
Pending test result: Indicates that the test is still in process. Donors can expect to receive the results of their antibody test within one to two weeks through our Red Cross Blood Donor app or online donor portal.
Inconsistent test result: Indicates that the Red Cross found different test results for COVID-19 antibodies after secondary testing. For example, a donation test result was initial positive for COVID-19 antibodies, while secondary testing results came back negative for COVID-19 antibodies. As with all tests, false positives, or a test result that incorrectly states the presence of antibodies, can occur. Alternatively, the level of COVID-19 antibodies may be too low to be detected by the second test. The Red Cross may contact you to request additional information.
Not Available test result: While rare, some donations may not be able to be tested due to processing issues. Donors will need to have a successful donation to receive COVID-19 antibody results. Per standard procedures, only successful donations are sent to our laboratory for testing.
For additional information about your test result, you may download or view the manufacturer’s fact sheet for the ORTHO Clinical Diagnostics VITROS® Total Test or the Roche Diagnostics Test.
