The ARC is at the leading edge of investigations into iron depletion in blood donors. Recently, this has included studies of prevalence of and risk factors for iron depletion, and current efforts are oriented more to adverse consequences resulting from iron depletion and potential mitigation options. Current studies are collecting information on the practice of and motivations for iron supplementation and simulations of different iron depletion mitigation strategies to assess likely efficacy and impact on blood availability.
Spencer BR, Guo Y, Cable RG, Kiss JE, Busch MP, Page GP, Endres-Dighe SM, Kleinman S, Glynn SA, Mast AE; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Iron status and risk factors for iron depletion in a racially/ethnically diverse blood donor population. Transfusion. 2019. [Epub ahead of print]
Spencer BR, Bialkowski W, Creel DV, Cable RG, Kiss JE, Stone M, McClure C, Kleinman S, Glynn SA, Mast AE; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) Program. Elevated risk for iron depletion in high-school age blood donors. Transfusion. 2019;59(5):1706-1716.