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REDS-III Research Program

The American Red Cross, Connecticut Region is pleased to announce its selection for participation in the REDS-III research program. Financed by the National Heart Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH), REDS-III (Recipient Epidemiology and Donor Evaluation Study-III) brings together leading researchers from the U.S. and abroad in the fields of blood banking and transfusion medicine.  Continuing the efforts of REDS and REDS-II to improve blood safety and availability, REDS-III seeks to improve transfusion practices and outcomes in recipients of blood products, both in the U.S. and internationally. 

The Connecticut Region is partnered with Yale-New Haven Hospital and Bridgeport Hospital to form one of four domestic “hubs” chosen for REDS-III. Each hub consists of a blood center and transfusion services that support one or more tertiary care and community hospitals.   The Yale-ARC hub is headed by Principal Investigator, Dr. Edward Snyder, at Yale University School of Medicine, and the American Red Cross effort is lead by Co-Principal Investigator, Dr. Ritchard Cable.  They will be supported by REDS-III Program Manager, Bryan Spencer, as well as by Co-Investigators Dr. Pat Pisciotto and Dr. Jorge Rios.

With REDS-III being the leading NIH program of epidemiological research on blood safety and availability, we are very pleased to have been selected for this competitive program.  Joining us as domestic hubs are investigators from the BloodCenter of Wisconsin, Milwaukee, WI; the Institute for Transfusion Medicine, Pittsburgh, PA; and University of California, San Francisco, San Francisco, CA.  Three international collaborative programs involving researchers in the U.S. and Brazil, China, and South Africa will participate in REDS-III, and the entire program will be supported by Research Triangle Institute as data coordinating center and Blood Systems Research Institute as central laboratory.

The Connecticut Region’s participation in REDS-III extends a lengthy history of research collaboration between New England and Connecticut Regions.  Having worked together on various projects for more than a decade, personnel from both regions supported the participation of New England Region in the REDS-II program, from 2004-2010.  With the mandate to study blood safety and availability, the REDS-II research portfolio covered topics that included the risk for iron depletion in frequent blood donors, risk for vasovagal reactions in young donors, and impact on blood availability implied by different potential TRALI mitigation efforts.  While REDS and REDS-II focused on donor populations, REDS-III takes the next step of trying to identify and describe the determinants of patient outcomes after receipt of blood products.

We look forward to sharing more information as the REDS-III portfolio develops and to working together in ensuring the success of the program.

To learn more about the REDS-III research program please click on the following link.